Mouse Steap3 activation kit by CRISPRa

CAT#: GA207809

Steap3 CRISPRa kit - CRISPR gene activation of mouse STEAP family member 3

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Steap3
• Locus ID: 68428
• Kit Components:

  GA207809G1, Steap3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA207809G2, Steap3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA207809G3, Steap3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001085409, NM_133186
• UniProt ID: Q8CI59
• Synonyms: 1010001D01Rik; pHyde; Tsap6
• Summary: Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Also mediates reduction of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.[UniProtKB/Swiss-Prot Function]