Mouse Ap4b1 activation kit by CRISPRa

CAT#: GA207359

Ap4b1 CRISPRa kit - CRISPR gene activation of mouse adaptor-related protein complex AP-4, beta 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Ap4b1
• Locus ID: 67489
• Kit Components:

  GA207359G1, Ap4b1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA207359G2, Ap4b1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA207359G3, Ap4b1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001163552, NM_001163553, NM_026193
• UniProt ID: Q9WV76
• Synonyms: 1810038H16Rik; Ap4b4; AV004952
• Summary: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (By similarity). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (PubMed:18341993). AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (By similarity).[UniProtKB/Swiss-Prot Function]