Mouse Mfn1 activation kit by CRISPRa

CAT#: GA207312

Mfn1 CRISPRa kit - CRISPR gene activation of mouse mitofusin 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Mfn1
• Locus ID: 67414
• Kit Components:

  GA207312G1, Mfn1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA207312G2, Mfn1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA207312G3, Mfn1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_024200
• UniProt ID: Q811U4
• Synonyms: 2310002F04Rik; 6330416C07Rik; D3Ertd265e; HR2; mKIAA4032
• Summary: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12527753, PubMed:23921378, PubMed:24513856, PubMed:15297672). Membrane clustering requires GTPase activity (By similarity). It may involve a major rearrangement of the coiled coil domains (PubMed:15297672). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12527753). Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity (By similarity).[UniProtKB/Swiss-Prot Function]