Mouse Polr3k activation kit by CRISPRa

CAT#: GA207077

Polr3k CRISPRa kit - CRISPR gene activation of mouse polymerase (RNA) III (DNA directed) polypeptide K

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Polr3k
• Locus ID: 67005
• Kit Components:

  GA207077G1, Polr3k gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA207077G2, Polr3k gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA207077G3, Polr3k gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_025901
• UniProt ID: Q9CQZ7
• Synonyms: 12.3kDa; 1500004O14Rik; AI196849; AU014893; C11; RPC10; RPC11
• Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).[UniProtKB/Swiss-Prot Function]