Mouse Edem3 activation kit by CRISPRa

CAT#: GA207055

Edem3 CRISPRa kit - CRISPR gene activation of mouse ER degradation enhancer, mannosidase alpha-like 3

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Edem3
• Locus ID: 66967
• Kit Components:

  GA207055G1, Edem3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA207055G2, Edem3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA207055G3, Edem3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001039644, NM_001311165, NM_001311166
• UniProt ID: Q2HXL6
• Synonyms: 2310050N11Rik
• Summary: Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity.[UniProtKB/Swiss-Prot Function]