Mouse Parva activation kit by CRISPRa

CAT#: GA206170

Parva CRISPRa kit - CRISPR gene activation of mouse parvin, alpha

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Parva
• Locus ID: 57342
• Kit Components:

  GA206170G1, Parva gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA206170G2, Parva gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA206170G3, Parva gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020606
• UniProt ID: Q9EPC1
• Synonyms: 2010012A22Rik; 5430400F08Rik; Actp; AI225929; AU042898; CH-ILKBP; Parvin
• Summary: Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development.[UniProtKB/Swiss-Prot Function]