Mouse Tollip activation kit by CRISPRa

CAT#: GA205717

Tollip CRISPRa kit - CRISPR gene activation of mouse toll interacting protein

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Tollip
• Locus ID: 54473
• Kit Components:

  GA205717G1, Tollip gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA205717G2, Tollip gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA205717G3, Tollip gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001347562, NM_023764
• UniProt ID: Q9QZ06
• Synonyms: 4930403G24Rik; 4931428G15Rik
• Summary: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).[UniProtKB/Swiss-Prot Function]