Mouse Clca1 activation kit by CRISPRa

CAT#: GA204778

Clca1 CRISPRa kit - CRISPR gene activation of mouse chloride channel accessory 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Clca1
• Locus ID: 23844
• Kit Components:

  GA204778G1, Clca1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204778G2, Clca1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204778G3, Clca1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_017474
• UniProt ID: Q9D7Z6
• Synonyms: Clca2; Clca3; gob-5; gob5
• Summary: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.[UniProtKB/Swiss-Prot Function]