Mouse Wnt1 activation kit by CRISPRa

CAT#: GA204631

Wnt1 CRISPRa kit - CRISPR gene activation of mouse wingless-type MMTV integration site family, member 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Wnt1
• Locus ID: 22408
• Kit Components:

  GA204631G1, Wnt1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204631G2, Wnt1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204631G3, Wnt1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_021279
• UniProt ID: P04426
• Synonyms: Int-1; sw; swaying; Wnt-1
• Summary: Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (PubMed:15454084, PubMed:16116452). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (PubMed:2202907, PubMed:16116452). Has a role in osteoblast function, bone development and bone homeostasis (By similarity).[UniProtKB/Swiss-Prot Function]