Mouse Eif4h activation kit by CRISPRa

CAT#: GA204622

Eif4h CRISPRa kit - CRISPR gene activation of mouse eukaryotic translation initiation factor 4H

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Eif4h
• Locus ID: 22384
• Kit Components:

  GA204622G1, Eif4h gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204622G2, Eif4h gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204622G3, Eif4h gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_033561
• UniProt ID: Q9WUK2
• Synonyms: AU018978; D5Ertd355e; E430026L18Rik; Ef4h; eIF-4H; Wbscr1; Wscr1
• Summary: This gene encodes eukaryotic translation initiation factor 4H (eIF4H) that plays a critical role in the process of protein synthesis. The encoded protein is an RNA-binding protein that, in concert with other translation initiation factors, helps unwind the 5' cap-proximal region of mRNA to prepare it for ribosomal attachment. Mice lacking the encoded protein displayed growth retardation with a significant reduction of body weight, a smaller brain volume and altered brain morphology. Behaviorally, mice lacking the encoded protein exhibit severe impairments of fear-related associative learning and memory formation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]