Mouse Timeless activation kit by CRISPRa

CAT#: GA204351

Timeless CRISPRa kit - CRISPR gene activation of mouse timeless circadian clock 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Timeless
• Locus ID: 21853
• Kit Components:

  GA204351G1, Timeless gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204351G2, Timeless gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204351G3, Timeless gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001136082, NM_001164080, NM_001164081, NM_011589
• UniProt ID: Q9R1X4
• Synonyms: C77407; Debt69; tim
• Summary: The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]