Mouse Slc12a3 activation kit by CRISPRa

CAT#: GA203928

Slc12a3 CRISPRa kit - CRISPR gene activation of mouse solute carrier family 12, member 3

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Slc12a3
• Locus ID: 20497
• Kit Components:

  GA203928G1, Slc12a3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203928G2, Slc12a3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203928G3, Slc12a3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001205311, NM_019415
• UniProt ID: P59158
• Synonyms: AI035291; NCC; NCCT; TSC
• Summary: Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (By similarity). Receptor for the proinflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1 (PubMed:26099046).[UniProtKB/Swiss-Prot Function]