Mouse Fmo3 activation kit by CRISPRa

CAT#: GA201452

Fmo3 CRISPRa kit - CRISPR gene activation of mouse flavin containing monooxygenase 3

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Fmo3
• Locus ID: 14262
• Kit Components:

  GA201452G1, Fmo3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA201452G2, Fmo3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA201452G3, Fmo3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008030
• UniProt ID: P97501
• Synonyms: AW111792
• Summary: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.[UniProtKB/Swiss-Prot Function]