Mouse Ercc1 activation kit by CRISPRa

CAT#: GA201285

Ercc1 CRISPRa kit - CRISPR gene activation of mouse excision repair cross-complementing rodent repair deficiency, complementation group 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Ercc1
• Locus ID: 13870
• Kit Components:

  GA201285G1, Ercc1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA201285G2, Ercc1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA201285G3, Ercc1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001127324, NM_007948
• UniProt ID: P07903
• Synonyms: Ercc-1
• Summary: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity).[UniProtKB/Swiss-Prot Function]