Mouse Cirbp activation kit by CRISPRa

CAT#: GA200733

Cirbp CRISPRa kit - CRISPR gene activation of mouse cold inducible RNA binding protein

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Cirbp
• Locus ID: 12696
• Kit Components:

  GA200733G1, Cirbp gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA200733G2, Cirbp gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA200733G3, Cirbp gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007705, NR_152857
• UniProt ID: P60824
• Synonyms: Cirp; R74941
• Summary: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpressed. Seems to play an essential role in cold-induced suppression of cell proliferation. Acts as a translational repressor. Acts as a translational activator. Binds specifically to the 3'-untranslated regions (3' UTRs) of stress-responsive transcripts RPA2 and TXN.[UniProtKB/Swiss-Prot Function]