Mouse Casp8 activation kit by CRISPRa

CAT#: GA200541

Casp8 CRISPRa kit - CRISPR gene activation of mouse caspase 8

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Casp8
• Locus ID: 12370
• Kit Components:

  GA200541G1, Casp8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA200541G2, Casp8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA200541G3, Casp8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001080126, NM_001277926, NM_009812
• UniProt ID: O89110
• Synonyms: CASP-8; FLICE; MACH; Mch5
• Summary: This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]