Human Histone H3.3C (H3F3C) activation kit by CRISPRa

CAT#: GA118436

H3F3C CRISPRa kit - CRISPR gene activation of human H3 histone family member 3C

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: H3-5
• Locus ID: 440093
• Kit Components:

  GA118436G1, Histone H3.3C gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA118436G2, Histone H3.3C gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA118436G3, Histone H3.3C gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001013699
• UniProt ID: Q6NXT2
• Synonyms: H3.5
• Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. [provided by RefSeq, Oct 2015]