Human TMIE activation kit by CRISPRa

CAT#: GA116909

TMIE CRISPRa kit - CRISPR gene activation of human transmembrane inner ear

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: TMIE
• Locus ID: 259236
• Kit Components:

  GA116909G1, TMIE gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA116909G2, TMIE gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA116909G3, TMIE gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_147196, NM_001370524, NM_001370525
• UniProt ID: Q8NEW7
• Synonyms: DFNB6
• Summary: This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment. [provided by RefSeq, Mar 2009]