Human KLB activation kit by CRISPRa

CAT#: GA115846

KLB CRISPRa kit - CRISPR gene activation of human klotho beta

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: KLB
• Locus ID: 152831
• Kit Components:

  GA115846G1, KLB gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA115846G2, KLB gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA115846G3, KLB gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_175737
• UniProt ID: Q86Z14
• Synonyms: BKL
• Summary: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).[UniProtKB/Swiss-Prot Function]