Human RLTPR (CARMIL2) activation kit by CRISPRa

CAT#: GA115548

CARMIL2 CRISPRa kit - CRISPR gene activation of human capping protein regulator and myosin 1 linker 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: CARMIL2
• Locus ID: 146206
• Kit Components:

  GA115548G1, RLTPR gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA115548G2, RLTPR gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA115548G3, RLTPR gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001013838, NM_001317026
• UniProt ID: Q6F5E8
• Synonyms: CARMIL2b; LRRC16C; RLTPR
• Summary: This gene encodes a member of the CARMIL (capping protein, Arp2/3, myosin-I linker) family of proteins. The encoded protein interacts with and negatively regulates the heterodimeric capping protein and promotes cell migration. Reduced expression of this gene has been observed in human psoriasis patients. Mutations in this gene cause a human immunodeficiency syndrome characterized by smooth muscle tumors and impaired T-cell function. [provided by RefSeq, May 2017]