Human Keratin 80 (KRT80) activation kit by CRISPRa

CAT#: GA115500

KRT80 CRISPRa kit - CRISPR gene activation of human keratin 80

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: KRT80
• Locus ID: 144501
• Kit Components:

  GA115500G1, Keratin 80 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA115500G2, Keratin 80 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA115500G3, Keratin 80 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001081492, NM_182507
• UniProt ID: Q6KB66
• Synonyms: KB20
• Summary: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.[provided by RefSeq, Oct 2010]