Human ZFYVE27 activation kit by CRISPRa

CAT#: GA114674

ZFYVE27 CRISPRa kit - CRISPR gene activation of human zinc finger FYVE-type containing 27

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: ZFYVE27
• Locus ID: 118813
• Kit Components:

  GA114674G1, ZFYVE27 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA114674G2, ZFYVE27 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA114674G3, ZFYVE27 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001002261, NM_001002262, NM_001174119, NM_001174120, NM_001174121, NM_001174122, NM_144588
• UniProt ID: Q5T4F4
• Synonyms: PROTRUDIN; SPG33
• Summary: This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]