Human PIK3AP1 activation kit by CRISPRa

CAT#: GA114672

PIK3AP1 CRISPRa kit - CRISPR gene activation of human phosphoinositide-3-kinase adaptor protein 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: PIK3AP1
• Locus ID: 118788
• Kit Components:

  GA114672G1, PIK3AP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA114672G2, PIK3AP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA114672G3, PIK3AP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_152309
• UniProt ID: Q6ZUJ8
• Synonyms: BCAP
• Summary: Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.[UniProtKB/Swiss-Prot Function]