Human Nac1 (NACC1) activation kit by CRISPRa

CAT#: GA114379

NACC1 CRISPRa kit - CRISPR gene activation of human nucleus accumbens associated 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: NACC1
• Locus ID: 112939
• Kit Components:

  GA114379G1, Nac1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA114379G2, Nac1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA114379G3, Nac1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_052876
• UniProt ID: Q96RE7
• Synonyms: BEND8; BTBD14B; BTBD30; NAC-1; NAC1
• Summary: This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012]