Human PNPT1 activation kit by CRISPRa

CAT#: GA113917

PNPT1 CRISPRa kit - CRISPR gene activation of human polyribonucleotide nucleotidyltransferase 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: PNPT1
• Locus ID: 87178
• Kit Components:

  GA113917G1, PNPT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA113917G2, PNPT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA113917G3, PNPT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_033109
• UniProt ID: Q8TCS8
• Synonyms: COXPD13; DFNB70; old-35; OLD35; PNPASE
• Summary: The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7. [provided by RefSeq, Dec 2012]