Human Aph 1b (APH1B) activation kit by CRISPRa

CAT#: GA113180

APH1B CRISPRa kit - CRISPR gene activation of human aph-1 homolog B, gamma-secretase subunit

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: APH1B
• Locus ID: 83464
• Kit Components:

  GA113180G1, Aph 1b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA113180G2, Aph 1b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA113180G3, Aph 1b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145646, NM_031301
• UniProt ID: Q8WW43
• Synonyms: APH-1B; PRO1328; PSFL; TAAV688
• Summary: This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]