Human TLR10 activation kit by CRISPRa

CAT#: GA113121

TLR10 CRISPRa kit - CRISPR gene activation of human toll like receptor 10

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: TLR10
• Locus ID: 81793
• Kit Components:

  GA113121G1, TLR10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA113121G2, TLR10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA113121G3, TLR10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001017388, NM_001195106, NM_001195107, NM_001195108, NM_030956
• UniProt ID: Q9BXR5
• Synonyms: CD290
• Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]