Human GCOM1 (POLR2M) activation kit by CRISPRa

CAT#: GA113041

POLR2M CRISPRa kit - CRISPR gene activation of human RNA polymerase II subunit M

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: POLR2M
• Locus ID: 81488
• Kit Components:

  GA113041G1, GCOM1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA113041G2, GCOM1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA113041G3, GCOM1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001018102, NM_001018103, NM_015532, NR_027390
• UniProt ID: P0CAP1
• Synonyms: GCOM1; Gdown; Gdown1; GRINL1A
• Summary: This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013]