Human TBC1D17 activation kit by CRISPRa

CAT#: GA112588

TBC1D17 CRISPRa kit - CRISPR gene activation of human TBC1 domain family member 17

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: TBC1D17
• Locus ID: 79735
• Kit Components:

  GA112588G1, TBC1D17 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA112588G2, TBC1D17 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA112588G3, TBC1D17 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001168222, NM_024682
• UniProt ID: Q9HA65
• Synonyms: FLJ12168
• Summary: Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known.[UniProtKB/Swiss-Prot Function]