Human Apoptosis enhancing nuclease (AEN) activation kit by CRISPRa

CAT#: GA112143

AEN CRISPRa kit - CRISPR gene activation of human apoptosis enhancing nuclease

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: AEN
• Locus ID: 64782
• Kit Components:

  GA112143G1, Apoptosis enhancing nuclease gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA112143G2, Apoptosis enhancing nuclease gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA112143G3, Apoptosis enhancing nuclease gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_022767
• UniProt ID: Q8WTP8
• Synonyms: ISG20L1; pp12744
• Summary: Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.[UniProtKB/Swiss-Prot Function]