Human HS3ST6 activation kit by CRISPRa

CAT#: GA112109

HS3ST6 CRISPRa kit - CRISPR gene activation of human heparan sulfate-glucosamine 3-sulfotransferase 6

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: HS3ST6
• Locus ID: 64711
• Kit Components:

  GA112109G1, HS3ST6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA112109G2, HS3ST6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA112109G3, HS3ST6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001009606
• UniProt ID: Q96QI5
• Synonyms: 3-OST-6; HS3ST5
• Summary: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.[UniProtKB/Swiss-Prot Function]