Human NDST4 activation kit by CRISPRa

CAT#: GA112090

NDST4 CRISPRa kit - CRISPR gene activation of human N-deacetylase and N-sulfotransferase 4

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: NDST4
• Locus ID: 64579
• Kit Components:

  GA112090G1, NDST4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA112090G2, NDST4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA112090G3, NDST4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_022569
• UniProt ID: Q9H3R1
• Synonyms: N-HSST; N-HSST 4; NDST-4; NHSST4
• Summary: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity).[UniProtKB/Swiss-Prot Function]