Human RNF70 (PJA1) activation kit by CRISPRa

CAT#: GA112017

PJA1 CRISPRa kit - CRISPR gene activation of human praja ring finger ubiquitin ligase 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: PJA1
• Locus ID: 64219
• Kit Components:

  GA112017G1, RNF70 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA112017G2, RNF70 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA112017G3, RNF70 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001032396, NM_022368, NM_145119
• UniProt ID: Q8NG27
• Synonyms: PRAJA1; RNF70
• Summary: This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked cognitive disability disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]