Human GPATCH3 activation kit by CRISPRa

CAT#: GA111909

GPATCH3 CRISPRa kit - CRISPR gene activation of human G-patch domain containing 3

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: GPATCH3
• Locus ID: 63906
• Kit Components:

  GA111909G1, GPATCH3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111909G2, GPATCH3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111909G3, GPATCH3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_022078
• UniProt ID: Q96I76
• Synonyms: GPATC3
• Summary: Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development (PubMed:28397860). Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 (PubMed:28414768).[UniProtKB/Swiss-Prot Function]