Human WDR19 activation kit by CRISPRa

CAT#: GA111717

WDR19 CRISPRa kit - CRISPR gene activation of human WD repeat domain 19

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: WDR19
• Locus ID: 57728
• Kit Components:

  GA111717G1, WDR19 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111717G2, WDR19 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111717G3, WDR19 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001317924, NM_025132
• UniProt ID: Q8NEZ3
• Synonyms: ATD5; CED4; DYF-2; IFT144; NPHP13; ORF26; Oseg6; PWDMP; SRTD5
• Summary: The protein encoded by this gene is a member of the WD (tryptophan-aspartic acid) repeat family, which is a large family of structurally-related proteins known to participate in a wide range of cellular processes. Each WD repeat typically contains about 40 amino acids that are usually bracketed by glycine-histidine and tryptophan-aspartic acid (WD) dipeptides. This protein contains six WD repeats, three transmembrane domains, and a clathrin heavy-chain repeat. Mutations in this gene have been described in individuals with a wide range of disorders affecting function of the cilium. These disorders are known as ciliopathies, and include Jeune syndrome, Sensenbrenner syndromes, Senior-Loken syndrome, combined or isolated nephronophthisis (NPHP), and retinitis pigmentosa (RP). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]