Human CHRNA10 activation kit by CRISPRa

CAT#: GA111351

CHRNA10 CRISPRa kit - CRISPR gene activation of human cholinergic receptor nicotinic alpha 10 subunit

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: CHRNA10
• Locus ID: 57053
• Kit Components:

  GA111351G1, CHRNA10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111351G2, CHRNA10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111351G3, CHRNA10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001303034, NM_001303035, NM_020402
• UniProt ID: Q9GZZ6
• Summary: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.[UniProtKB/Swiss-Prot Function]