Human MCCC1 activation kit by CRISPRa

CAT#: GA111272

MCCC1 CRISPRa kit - CRISPR gene activation of human methylcrotonoyl-CoA carboxylase 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: MCCC1
• Locus ID: 56922
• Kit Components:

  GA111272G1, MCCC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111272G2, MCCC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111272G3, MCCC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001293273, NM_020166, NR_120639, NR_120640, NM_001363880
• UniProt ID: Q96RQ3
• Synonyms: MCC-B; MCCA
• Summary: This gene encodes the large subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. [provided by RefSeq, Jul 2008]