Human TBC1D2 activation kit by CRISPRa

CAT#: GA110734

TBC1D2 CRISPRa kit - CRISPR gene activation of human TBC1 domain family member 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: TBC1D2
• Locus ID: 55357
• Kit Components:

  GA110734G1, TBC1D2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA110734G2, TBC1D2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA110734G3, TBC1D2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001267571, NM_001267572, NM_018421, NR_051978
• UniProt ID: Q9BYX2
• Synonyms: PARIS-1; PARIS1; TBC1D2A
• Summary: Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.[UniProtKB/Swiss-Prot Function]