Human PNPO activation kit by CRISPRa

CAT#: GA110565

PNPO CRISPRa kit - CRISPR gene activation of human pyridoxamine 5'-phosphate oxidase

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: PNPO
• Locus ID: 55163
• Kit Components:

  GA110565G1, PNPO gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA110565G2, PNPO gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA110565G3, PNPO gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_018129
• UniProt ID: Q9NVS9
• Synonyms: HEL-S-302; PDXPO
• Summary: The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy. [provided by RefSeq, Oct 2008]