Human RAP80 (UIMC1) activation kit by CRISPRa

CAT#: GA109959

UIMC1 CRISPRa kit - CRISPR gene activation of human ubiquitin interaction motif containing 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: UIMC1
• Locus ID: 51720
• Kit Components:

  GA109959G1, RAP80 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA109959G2, RAP80 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA109959G3, RAP80 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199297, NM_001199298, NM_001317961, NM_016290, NR_146149, NR_146150
• UniProt ID: Q96RL1
• Synonyms: RAP80; X2HRIP110
• Summary: This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]