Human PHF20 activation kit by CRISPRa

CAT#: GA109662

PHF20 CRISPRa kit - CRISPR gene activation of human PHD finger protein 20

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: PHF20
• Locus ID: 51230
• Kit Components:

  GA109662G1, PHF20 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA109662G2, PHF20 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA109662G3, PHF20 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016436
• UniProt ID: Q9BVI0
• Synonyms: C20orf104; GLEA2; HCA58; NZF; TDRD20A; TZP
• Summary: Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.[UniProtKB/Swiss-Prot Function]