Human PPPDE1 (DESI2) activation kit by CRISPRa

CAT#: GA109512

DESI2 CRISPRa kit - CRISPR gene activation of human desumoylating isopeptidase 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: DESI2
• Locus ID: 51029
• Kit Components:

  GA109512G1, PPPDE1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA109512G2, PPPDE1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA109512G3, PPPDE1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001297746, NM_016076, NR_123735, NR_123736
• UniProt ID: Q9BSY9
• Synonyms: C1orf121; CGI-146; DESI; DeSI-2; DESI1; FAM152A; PNAS-4; PPPDE1
• Summary: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization (PubMed:28483520).[UniProtKB/Swiss-Prot Function]