Human DUOX2 activation kit by CRISPRa

CAT#: GA109419

DUOX2 CRISPRa kit - CRISPR gene activation of human dual oxidase 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: DUOX2
• Locus ID: 50506
• Kit Components:

  GA109419G1, DUOX2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA109419G2, DUOX2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA109419G3, DUOX2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014080, NM_001363711
• UniProt ID: Q9NRD8
• Synonyms: LNOX2; NOXEF2; P138-TOX; TDH6; THOX2
• Summary: The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]