Human Hey L (HEYL) activation kit by CRISPRa

CAT#: GA108880

HEYL CRISPRa kit - CRISPR gene activation of human hes related family bHLH transcription factor with YRPW motif like

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: HEYL
• Locus ID: 26508
• Kit Components:

  GA108880G1, Hey L gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA108880G2, Hey L gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA108880G3, Hey L gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014571
• UniProt ID: Q9NQ87
• Synonyms: bHLHb33; HESR3; HEY3; HRT3
• Summary: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]