Human BRD4 activation kit by CRISPRa

CAT#: GA108333

BRD4 CRISPRa kit - CRISPR gene activation of human bromodomain containing 4

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: BRD4
• Locus ID: 23476
• Kit Components:

  GA108333G1, BRD4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA108333G2, BRD4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA108333G3, BRD4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001330384, NM_014299, NM_058243
• UniProt ID: O60885
• Synonyms: CAP; HUNK1; HUNKI; MCAP
• Summary: The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]