Human DCTN3 activation kit by CRISPRa

CAT#: GA107757

DCTN3 CRISPRa kit - CRISPR gene activation of human dynactin subunit 3

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: DCTN3
• Locus ID: 11258
• Kit Components:

  GA107757G1, DCTN3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA107757G2, DCTN3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA107757G3, DCTN3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001281425, NM_001281426, NM_001281427, NM_007234, NM_024348
• UniProt ID: O75935
• Synonyms: DCTN-22; DCTN22
• Summary: This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]