Human Nebulette (NEBL) activation kit by CRISPRa

CAT#: GA107195

NEBL CRISPRa kit - CRISPR gene activation of human nebulette

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: NEBL
• Locus ID: 10529
• Kit Components:

  GA107195G1, Nebulette gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA107195G2, Nebulette gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA107195G3, Nebulette gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001173484, NM_006393, NM_016365, NM_213569
• UniProt ID: O76041
• Synonyms: LASP2; LNEBL
• Summary: This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]