Human Lubricin (PRG4) activation kit by CRISPRa

CAT#: GA106946

PRG4 CRISPRa kit - CRISPR gene activation of human proteoglycan 4

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: PRG4
• Locus ID: 10216
• Kit Components:

  GA106946G1, Lubricin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106946G2, Lubricin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106946G3, Lubricin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001127708, NM_001127709, NM_001127710, NM_001303232, NM_005807
• UniProt ID: Q92954
• Synonyms: CACP; HAPO; JCAP; MSF; SZP
• Summary: The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]