Human ARFBP1 (HUWE1) activation kit by CRISPRa

CAT#: GA106828

HUWE1 CRISPRa kit - CRISPR gene activation of human HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1


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Find the corresponding CRISPRi Inhibitor Kit

USD 1,657.00

2 Weeks*

Size
    • 1 kit

Product Images

Frequently bought together (2)
Rabbit Polyclonal ARF-BP1 Antibody
    • 100 ug

USD 570.00


HUWE1 (Myc-DDK-tagged)-Human HECT, UBA and WWE domain containing 1 (HUWE1)
    • 10 ug

USD 5,216.00

Other products for "HUWE1"

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol HUWE1
Locus ID 10075
Kit Components

GA106828G1, ARFBP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA106828G2, ARFBP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA106828G3, ARFBP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_005703, NM_031407
UniProt ID Q7Z6Z7
Synonyms ARF-BP1; HECTH9; HSPC272; Ib772; LASU1; MULE; URE-B1; UREB1
Summary This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.