Human MUC12 activation kit by CRISPRa

CAT#: GA106825

MUC12 CRISPRa kit - CRISPR gene activation of human mucin 12, cell surface associated

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: MUC12
• Locus ID: 10071
• Kit Components:

  GA106825G1, MUC12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106825G2, MUC12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106825G3, MUC12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001164462
• UniProt ID: Q9UKN1
• Synonyms: MUC-11; MUC-12; MUC11
• Summary: This gene encodes an integral membrane glycoprotein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces and have been implicated in epithelial renewal and differentiation. These glycoproteins also play a role in intracellular signaling. This protein is expressed on the apical membrane surface of epithelial cells that line the mucosal surfaces of many different tissues including the colon, pancreas, prostate, and uterus. The expression of this gene is downregulated in colorectal cancer tissue. [provided by RefSeq, Apr 2017]